Center for Embryo Medicine center for embryo medicine
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How to work with CEM

Encrypted base system:

To speed up the report service and ensure its confidentiality, the Center for Embryo Medicine has created an easy to use encrypted Web platform at

To use this system it is necessary to register on the site. When a centre registers for the first time, it is given a user name as well as a personal and non-transferable password.

This platform also permits access to laboratory protocols and informed consent data, as well as a statistical system to properly supervise patients.

How to proceed for donors' genetic screening?

To carry out a genetic screening for donors or patients, a 3 ml blood sample in an EDTA tube is necessary.

The sample should be sent at room temperature in the following 24 hours after extraction. It should be kept refrigerated before delivery. CME provides the corresponding request form.

Results are delivered within 20 days after sample reception.

How to proceed for Preimplantation Genetic Diagnosis?

In PGD cases, two courses of actions are possible

  • CEM personnel can travel to the IVF centre and carry out the biopsy of the embryos or the fixation/tubing of the blastomeres.

  • Blastomeres can be sent already fixated or collected in PCR tubes to CEM

Slides with fixated nuclei must be sent duly protected and a conventional delivery service may be used.

Arter receiving the samples, the results are usually delivered in 24 hours.

How to proceed for Sperm FISH analysis?

To carry out Sperm FISH analysis, a semen sample obtained in a sterile recipient is necessary.

The sample must be sent at room temperature in a tube correctly sealed and labelled. It should be kept refrigerated before delivey. A conventional message service may be used.

Results are delivered in approximately 2 weeks.

How to proceed for Sperm DNA Fragmentation test?

To carry out Sperm DNA Fragmentation test, a semen sample obtained in a sterile recipient is necessary.

For the analysis of these samples it is preferable to fixate the sample at the time of collection, so it is advisable to send fixated samples. CEM provides the sperm fixation protocol.

Results are delivered in approximately 2 weeks.

How to proceed for PGD for a single gene disorder?

Currently, the Center for Embryo Medicine offers the study for over 200 single gene disorders. The list is constantly growing as it is possible to offer PGD for most conditions where a molecular diagnosis has been established.

In order to evaluate the case and determine whether PGD is feasible for a particular couple, the laboratory will require the following information:

  • Genetic report of the patients, detailing the disease and mutation.

  • Detailed family history.

Once the CEM team accepts the case an, a work-up study is necessary. This is a personalized study for the consulting couple where a technique is developed in order to test their embryos for the reported mutation. This study determines if a PGD test can be offered to the couple with a high accuracy level (~98%). In order to perform the work-up study, the laboratory will require a blood sample from both partners, as well as from other affected/carrier relatives, accompanied by the corresponding genetic reports.

Once the work-up study is completed,if PGD is feasible for the couple, the Preimplantation Genetic Diagnosis service will contact the centre toinform on the possibility of beginning the stimulation cycle.

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